The ERBB3 antibody from MyBioSource.com is a Mouse Monoclonal antibody to c-erbB-3, c-erbB3, ERBB3, and HER3. This antibody recognizes Human antigen. The ERBB3 antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Mouse monoclonal ERBB3 antibody
ERBB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation